Kliiniset tutkimukset

  • Julkaistut kliiniset tutkimukset osoittavat, että päivittäin käytettynä Actimel auttaa vahvistamaan elimistön luonnollista vastustuskykyä.
  • Julkaistut kliiniset tutkimukset tukevat tietoa Actimelin vaikutuksista immuunijärjestelmään.
  • Julkaistut kliiniset tutkimukset tukevat tietoa Actimelin vaikutuksista suoliston mikrobiflooraan.
  • Julkaistut kliiniset tutkimukset osoittavat, että L. casei Defensis (DN-114 001 / CNCM I-1518) selviytyy ruoansulatuskanavassa.
  • Uusia kliinisiä tutkimustuloksia Actimelin edullisista vaikutuksista elimistön luonnolliseen vastustuskykyyn on esitelty kansainvälisissä kongresseissa. Tulokset julkaistaan vuonna 2009.

    • Julkaistut kliiniset tutkimukset osoittavat, että päivittäin käytettynä Actimel auttaa vahvistamaan elimistön luonnollista vastustuskykyä.

    Kirjoittajat Otsikko Linkki artikkeliin
    Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV, Radaelli G. A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Pediatr Res. 2007 Aug;62(2):215-20.
    Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ. 2007 Jul 14;335(7610):80.
    Giralt J, Regadera JP, Verges R, Romero J, de la Fuente I, Biete A, Villoria J, Cobo JM, Guarner F. Effects of Probiotic Lactobacillus Casei DN-114 001 in Prevention of Radiation-Induced Diarrhea: Results from Multicenter, Randomized, Placebo-Controlled Nutritional Trial. Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1213-9
    Sýkora J, Valecková K, Amlerová J, Siala K, Dedek P, Watkins S, Varvarovská J, Stozický F, Pazdiora P, Schwarz J. Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study. J Clin Gastroenterol. 2005 Sep;39(8):692-8.
    Pereg D, Kimhi O, Tirosh A, Orr N, Kayouf R, Lishner M. The effect of fermented yogurt on the prevention of diarrhea in a healthy adult population. Am J Infect Control. 2005 Mar;33(2):122-5.
    Turchet P, Laurenzano M, Auboiron S, Antoine JM. Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study. J Nutr Health Aging. 2003;7(2):75-7.
    Agarwal KN, Bhasin SK. Feasibility studies to control acute diarrhoea in children by feeding fermented milk preparations Actimel and Indian Dahi. Eur J Clin Nutr 2002 Dec;56 Suppl 4:S56-9.
    Agarwal KN, Bhasin SK, Faridi MM, Mathur M, Gupta S. Lactobacillus casei in the control of acute diarrhea--a pilot study. Indian Pediatr. 2001 Aug;38(8):905-10.
    Pedone CA, Arnaud CC, Postaire ER, Bouley CF, Reinert P. Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea. Int J Clin Pract. 2000 Nov;54(9):568-71.
    Pedone CA, Bernabeu AO, Postaire ER, Bouley CF, Reinert P. The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres. Int J Clin Pract. 1999 Apr-May;53(3):179-84.

    Julkaistut kliiniset tutkimukset tukevat tietoa Actimelin vaikutuksista immuunijärjestelmään.

    Kirjoittajat Otsikko Linkki artikkeliin
    Ortiz-Andrellucchi A, Sánchez-Villegas A, Rodríguez-Gallego C, Lemes A, Molero T, Soria A, Peña-Quintana L, Santana M, Ramírez O, García J, Cabrera F, Cobo J, Serra-Majem L. Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei DN114001 in lactating mothers and their children. Br J Nutr. 2008 Oct;100(4):834-45
    Meyer AL, Elmadfa I, Herbacek I, Micksche M. Probiotic, as well as conventional yogurt, can enhance the stimulated production of proinflammatory cytokines. J Hum Nutr Diet 2007 Dec;20(6):590-8.
    Tiollier E, Chennaoui M, Gomez-Merino D, Drogou C, Filaire E, Guezennec CY. Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training. Mil Med. 2007 Sep;172(9):1006-11.
    Meyer AL, Micksche M, Herbacek I, Elmadfa I. Daily intake of probiotic as well as conventional yogurt has a stimulating effect on cellular immunity in young healthy women. Ann Nutr Metab. 2006;50(3):282-9.
    Marcos A, Wärnberg J, Nova E, Gómez S, Alvarez A, Alvarez R, Mateos JA, Cobo JM. The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114001 on the immune response of subjects under academic examination stress. Eur J Nutr. 2004 Dec;43(6):381-9.
    Parra MD, Martínez de Morentin BE, Cobo JM, Mateos A, Martínez JA. Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves innate-defense capacity in healthy middle-aged people. J Physiol Biochem. 2004 Jun;60(2):85-91.
    Parra D, De Morentin BM, Cobo JM, Mateos A, Martinez JA. Monocyte function in healthy middle-aged people receiving fermented milk containing Lactobacillus casei. J Nutr Health Aging. 2004;8(4):208-11.
    Pujol P, Huguet J, Drobnic F, Banquells M, Ruiz O, Galilea P, Segarra N, Aguilera S, Burnat A, Mateos JA, Postaire ER. The effect of fermented milk containing Lactobacillus casei on the immune response to exercise. Sports Med, Training and Rehab. 2000;9(3):209-223.
    Yoon H, Dubarry M, Bouley C, Meredith C, Portier A, Tome D, Renevot O, Blachon JL, Dugas B, Drewitt P, Postaire E. New insights in the validation of systemic biomarkers for the evaluation of the immunoregulatory properties of milk fermented with yogurt culture and Lactobacillus casei (Actimel®): A prospective trial. Int J Immunotherapy. 1999;15(2):79-89.
    Boge T, Rémigy M, Vaudaine S, Tanguy J, Bourdet-Sicard R, van der Werf S. A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine. 2009 Sep 18;27(41):5677-84. Epub 2009 Jul 16.
    Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Consumption of a fermented diary product containing the probiotic Lactobacillus case DN-144001 reduces the duration of respiratoru infections in the elderly in a randomised controlled trial. Br J Nutr. 2009 Sep 14:1-11.

    Julkaistut kliiniset tutkimukset tukevat tietoa Actimelin vaikutuksista suoliston mikrobiflooraan.

    Kirjoittajat Otsikko Linkki artikkeliin
    Pawlowska J, Klewicka E, Czubkowski P, Motyl I, Jankowska I, Libudzisz Z, Teisseyre M, Gliwicz D, Cukrowska B. Effect of Lactobacillus casei DN-114001 application on the activity of fecal enzymes in children after liver transplantation. Transplant Proc 2007 Dec;39(10):3219-21.
    Guerin-Danan C, Chabanet C, Pedone C, Popot F, Vaissade P, Bouley C, Szylit O, Andrieux C. Milk fermented with yogurt cultures and Lactobacillus casei compared with yogurt and gelled milk: influence on intestinal microflora in healthy infants. Am J Clin Nutr. 1998 Jan;67(1):111-7.

    Julkaistut kliiniset tutkimukset osoittavat, että L. casei Defensis (DN-114 001 / CNCM I-1518) selviytyy ruoansulatuskanavassa.

    Kirjoittajat Otsikko Linkki artikkeliin
    Rochet V, Rigottier-Gois L, Levenez F, Cadiou J, Marteau P, Bresson JL, Goupil-Feillerat N, Doré J. Modulation of Lactobacillus casei in ileal and fecal samples from healthy volunteers after consumption of a fermented milk containing Lactobacillus casei DN-114 001Rif Can J Microbiol 2008 Aug;54(8):660-7
    Oozeer R, Leplingard A, Mater DD, Mogenet A, Michelin R, Seksek I, Marteau P, Doré J, Bresson JL, Corthier G. Survival of Lactobacillus casei in the human digestive tract after consumption of fermented milk. Appl Environ Microbiol. 2006 Aug;72(8):5615-7.
    Rochet V, Rigottier-Gois L, Sutren M, Krementscki MN, Andrieux C, Furet JP, Tailliez P, Levenez F, Mogenet A, Bresson JL, Méance S, Cayuela C, Leplingard A, Doré J. Effects of orally administered Lactobacillus casei DN-114 001 on the composition or activities of the dominant faecal microbiota in healthy humans Br J Nutr. 2006 Feb;95(2):421-9.

    Uusia kliinisiä tutkimustuloksia Actimelin edullisista vaikutuksista elimistön luonnolliseen vastustuskykyyn on esitelty kansainvälisissä kongresseissa. Tulokset julkaistaan vuonna 2009.

    Tutkimuksen otsikko Esitelty
    A new randomized double blind controlled study measuring Actimel effects on natural defences of 638 children during winter period. (awaiting publication) Pediatric Academic Societies Annual Meeting; 2-6 May 2008 Honolulu Hawai, USA
    2nd Congress of the European Academy of Pediatrics (EAP); 24-28 Oct 2008 Nice, France
    6th meeting of the International Scientific Association for Probiotics and Prebiotics (ISAPP9-11); 9-11 Nov 2008 London Ontario, Canada
    A new randomized double blind controlled study measuring Actimel effects on natural defences of 599 children during winter period. (awaiting publication) XII Congress of Pediatricians of Russia; 19-22 Feb 2008 Moscow, Russia
    A new randomized double blind controlled study measuring Actimel effects on natural defences of 1000 adults during winter period. (awaiting publication) 2nd European Conference on Probiotics and their Applications; 15-17 Oct 2008 Cracow, Poland
    A new randomized double blind controlled study measuring Actimel effects on natural defences of 239 firemen during training period. (awaiting publication) World Congress of Sports Medicine; 18-23 Nov 2008 Barcelona, Spain